Berberine for Cardiovascular Health – And More

Berberine for Cardiovascular Health – And More

Berberine comes from several different plants, most commonly in shrubs from the berberis family, thus the name. It has been used for thousands of years for general health, especially in Chinese medicine. It is good for helping with many ailments because it can affect change at the molecular level. It is one of the few supplements that has been proven in studies to be as effective as drugs. And it has so many benefits!

 

A placebo-controlled study provided the first evidence that berberine is a valuable supplement for diabetes and cardiovascular health. Berberine was shown to lower blood glucose, HbA1c (the best measure of long-term blood sugar and diabetes control), triglycerides, total cholesterol and LDL cholesterol significantly better than a placebo in people with type 2 diabetes.

 

When type 2 diabetics were given either berberine or the diabetes drug metformin, the berberine was equally effective for blood glucose, HbA1c and insulin. Berberine had an advantage over the drug, though, because it also lowered cholesterol and triglycerides. The study also found that adding the same dose of berberine to the treatment of people whose type 2 diabetes was not being adequately managed by drugs significantly lowered blood glucose, HbA1c, triglycerides, total cholesterol and the harmful LDL cholesterol. This means that overall, berberine was effective enough to help lower blood sugar levels all on its own.

 

There have been many studies done where Berberine’s effectiveness was similar to conventional drugs. It has been shown to significantly lower fasting blood glucose levels, insulin, triglycerides and HbA1c in type 2 diabetics. It can also help to reverse high blood sugar in people who are considered pre-diabetic. This means it can help adults who are found in blood tests to have high triglycerides or blood sugar at the warning stage. There is nothing more alarming than the doctor telling you the blood sugar levels are creeping up and warning that you need to take steps now or risk medical interventions. A pill or more a day, or worse, needles. And either way, blood sugar monitoring. Taking Preferred Nutrition Berberine may be able to help at this crucial ‘warning stage’.

 

Studies have not only shown that Berberine was as effective as drugs for diabetes, but also that it may be equal to drugs for lowering total and LDL cholesterol and superior to drugs for lowering triglycerides and raising the heart-healthy HDL cholesterol. It also found that berberine is superior to placebos for high blood pressure. Furthermore, Berberine has also been shown to be beneficial in the treatment of arrhythmias and heart failure. Adding Berberine to conventional treatment of congestive heart failure has been shown to significantly improve the results and help to turn things around, in conjunction with other lifestyle changes.

 

Preferred Nutrition Berberine has many benefits!

Imagine How Great You Would Feel if You Absorbed More

Imagine How Great You Would Feel if You Absorbed More

At Platinum Naturals they understand absorption. Through their award-winning Superior Nutrient Absorption delivery system, they’re able to deliver the results people are looking for when they take a supplement. Whether it is increased energy, improved bone density or relief from cold and flu, Superior Nutrient Absorption helps ensure you absorb the nutrients your body needs for improved health.

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5 Reasons Your Probiotic Isn’t Working

5 Reasons Your Probiotic Isn’t Working

You buy a probiotic thinking that it will have an impact on how you feel. But when you start taking it, you feel nothing. Or worse, you feel more bloated and your digestion feels funnier than when you started. Here’s how to troubleshoot why your probiotic may not be working, and how to find a probiotic that will.

Probiotics can improve your health1. But if your probiotic isn’t working for you, it could be because of one (or more) of these reasons:

1. It contains allergens

If you have digestive issues, you may have food sensitivities, too. Look for a probiotic that’s free of the top eight allergens: milk, eggs, peanuts, tree nuts, fish, shellfish, soy and wheat.

2. It’s not the right probiotic for you

Your gut contains thousands of different species of probiotic bacteria, so you’ll likely benefit from a variety of strains. In 75% of the cases that evaluated multi vs. individual species formulas, the multi-strain formula worked better!

3. The bacteria aren’t alive

To feel a benefit, your probiotics must be living! Look for a probiotic with a guaranteed CFU at expiry, which indicates the bacteria guaranteed to be living by the time the probiotic expires.

4. The bacteria aren’t getting to your gut

Your probiotics must make it through your stomach acid and reach your gut alive.Look for a probiotic encapsulated in a delayed-release capsule that will get them there.

5. It doesn’t contain balanced strains

If your multi-strain doesn’t feel like it’s doing a good job, it could be because the strains aren’t balanced. Look for a probiotic that lists all strains and their amounts on the label.

Genuine Health spent a lot of time creating advanced gut health probiotics so they would make a difference in how you feel:

  • Crafted with 15 balanced strains of probiotic bacteria with an ample CFU
  • Strains are triple cleaned to ensure that only the heartiest remain
  • Encapsulated in a delayed-release, plastic-free capsule that’s been shown to deliver up to 10x the bacteria to the gut
  • Shelf stable and packed in a humidity-resistant blister pack
  • Vegan and free of allergens like gluten, wheat,dairy, nuts, fish, eggs and sulphites
Advanced Gut Health 
Probiotic by Genuine health
50 Billion CFU

1Taibi, et al. Practical approaches to probiotics use. Appl Physiol Nutr Metab. 2014 Aug;39(8):980-6

Curcumin BDM30 or Higher

Curcumin BDM30 or Higher

Look for products made with Curcumin BDM30™

Curcumin is quickly becoming a household name and noted to be one of the more potent anti-inflammatory agents among the natural therapies. We hear about its application in the treatment of Alzheimer’s,depression, colitis, Crohn’s, arthritis, injuries, hypertension,hypercholesterolemia and so much more. Despite its effectiveness for some people and some conditions, lack of reliability or consistent results is an ongoing problem even for long term users. So is this hit and miss miracle from nature supported by research?

One main reason curcumin can be applied with reasonable effect to treat many of these conditions is inflammation is a fundamental process or chemistry that is common to most if not every disease we face. This includes diseases like depression that appear to be far removed from our mainstream notion of inflammation. Most drugs we use to treat disease today are effective at neutralising this inflammatory activity in target tissues or cells. The different drugs target different proteins involved in this long pathway to immune system and inflammatory activity.

Typically, a unique disease is characterized by a mutation or regulatory anomaly of a unique protein involved in these inflammatory pathways. They work much like dominoes that keep the flow going in an intended direction. If one domino in the line is damaged or warped it could alter the pathway. In a very simple model like this each domino represents a regulatory protein in the long pathway; each ever-so-slightly- guiding the flow. A unique drug targeting this damaged protein, for instance, may inhibit the inflammatory process with precision for this disorder if it corrects completely or to a degree it counters the activity of this specific malfunctioning protein. Nevertheless, by targeting other proteins in the same pathway to slow down the flow, we can slow down inflammation sometimes additively.

Research shows curcumin to be a mildly effective inhibitor of a key protein called a transcription factor (namely NF-kB) involved in the escalation of inflammation. Other proteins are affected as well but we will keep this simple. Poorly regulated NF-kB escalates inflammation by literally transcribing, at the genetic level, cytokines such as TNFα and many others. If pushed out of control by a genetic mutation or damage of a naturally built-in regulatory loop the transcription (or production) stays ON too long without controls. Curcumin can be used to take the edge off many disorders because it slows down NF-kB but it can only do so if it is properly extracted to yield the right proportions of the subfraction curcuminoids.

Regular old curcumin (even curcumin 95%) is not reliable and is usually not potent enough to deal with deep rooted inflammation that is caused by damage to regulatory systems beyond NF-kB. (inflammation can be escalated by mutations leading to poor regulation of other key proteins in the same LONG pathway. These key proteins are often referred to as ‘drug targets’by pharma researchers because they represent stop points in the expansive pathway where a drug could make a difference if it were able to modulate the protein.

The latest research discovery at Biologic Pharmamedical Research shows us that these underlying curcuminoid components in the curcumin extract have different drug target activity. They can target different regulatory proteins; some of which are in that inflammatory pathway. Treatment success with regular curcumin that is not standardised with regards to the curcuminoid proportions within the curcumin extract is therefore different from one curcumin 95% extract to another curcumin 95% extract. ANY OLD CURCUMIN IS SIMPLY NOT ANY OLD CURCUMIN!

It’s important to highlight that within the typical curcumin 95% extract three curcuminoids make up the 95% concentration. The problem is that from curcumin extract to extract these underlying curcuminoid proportions fluctuate and do so even for the same brand from batch to batch or lot to lot.

Our recent research, at Biologic Pharmamedical Research has been focused on separating, isolating and mapping the pharmacology of these curcuminoid components in the context of multiple key proteins in this inflammatory pathway. Then to study each contribute in isolation to see how they modulate anti-inflammatory activity and other subcellular activities that help neutralise disease symptoms. The findings have led to game changing insight that puts a completely new perspective on curcumin and a new standard of drug design.

These curcuminoids can each have distinct pharmacological activity inside our cells targeting different proteins. One new one was discovered by Biologic Pharmamedical’s Franco Cavaleri PhDc. Even if you are certain you are buying a 95% extract every time, you do not have insight into how the underlying curcuminoid proportions have changed from your previous batch to alter the activity of your curcumin and your inflammation on the next purchase. Remember, the inflammatory pathway is comprised of a plethora of proteins that effect and regulate it from a 3 dimensional perspective. In addition keep in mind that NF-kB modulates as many as 150 genes!! This is complex and any minute shift produces monumental changes. In addition each protein is influenced, itself by a multitude of regulatory proteins any one of which could be defective in your specific disease state/pathology.

Our research at Biologic shows some of the newly discovered curcumioid activity to be synergistic to an intended therapeutic outcome. However, in other situations where the curcuminoid proportions shift the shifting can oppose an intended effect. Sometimes you get a potent 95 extract that works in your favour and other times you get a less effective one even though you think you have the same product.

The amazing knowledge to come out of this pharmaceutical research with these curcuminoids is a clearer understanding of the mechanism by which curcumin delivers its activity. In addition, we have found that nature has provided us with more intelligence within the curcumin extract that we are still working to extract. This latest ‘intelligence’ shows us an exponentially higher ORAC value that is measurably reliable: 125 x greater than regular curcumin. The key active curcuminoid fraction of this discovery is increased to 30% (ie BDM30) while regular curcumin only has 1% (ie BDM1) of this key active.  Each curcuminoid portion is locked in for consistency and standardised to be reliable from lot to lot.

Moreover, it has allowed us to stabilise and create proportions of these underlying curcuminoids that serve our inflammatory targets with greater precision and make certain this activity is consistent from lot to lot.

Purica Curcumin Extra Strength
30% BDMC Anti-Inflammatory - Rapid Relief.  Optimal Performance.

The result of this novel standard of curcumin pharmacology is BDM30™ -reliable curcuminoid composition standardisation; more effective measurement of activity; and consistent activity for curcumin that also exceeds 95% concentration! The patented Curcumin BDM30™ is the new household name used in the higher quality curcumin-based products. Look for products ‘made with BDM30’.

CONFLICT OF INTEREST STATEMENT: 

The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The research on these findings continues at clinical levels to further investigate the full indication-specific potential of this discovery. The author/researcher is also the owner of related Intellectual Properties.

Author copyright Franco Cavaleri PhDc

Attention Athletes, Active Adults and Seniors

Why wait days for optimal pain relief when you can have it in just a few short hours?

Life is precious. So is your time. Why waste any of it?

With PURICA Curcumin Extra Strength 30% BDMC Anti-Inflammatory, you’re getting remarkably fast-acting relief from inflammation and joint pain. At a potency of 30 times the regular curcumin extract, you can make sure that time and performance is on your side.

Clinically Proven to Work faster, better and longer

It is designed to help everyone (from high performance athletes and weekend warriors to health- conscious adults and active seniors) find fast relief from inflammation and joint pain.  

  • BDMC improves curcuminstability, bioavailability and prolonged survival in blood.   
  • BDMC offers an ORAC of 6,245,000 units!    Regular curcumin has an ORAC of just 9,500 units.  
  • BDMC inhibits NF-kB and MSK1 to combat inflammation from two targets.     Regular curcumin onlu inhibits NF-kB.  

Why the potency matters?

Powered by 30% BDMC, PURICA Curcumin quickly alleviates inflammation and relieves joint pain. And fast! The Rapid Relief leads the way to Optimal Performance, so that you can get back to what you love doing. Day in. Day out. It works better and longer for you.

Suggested dosing is only 1 capsule per day for to help with:

  • Better runs and walks.  Longer runs and walks.
  • Better workouts.  Longer work outs.  
  • Better fun.  Longer fun.  
  • Enhances detoxification.  
  • Promotes skin health.
  • Balances cholesterol.  
  • Regulates blood sugar.  
  • Helps prevent blood clots.
  • Boosts brain function.
Purica Curcumin is a Powerful 30% BDMC Anti-Inflammatory offering Rapid Relief, Optimal Performance, and Fast Relief.  

30 times the potency and up to 657 times more ant-oxidants that regular curcumin extract.

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