Published
http://www.ncbi.nlm.nih.gov/pubmed/24598438 Neurosci Lett. 2014 Apr 30;566:247-51. doi: 10.1016/j.neulet.2014.02.045. Epub 2014 Mar 2.
Anti-inflammatory effects of Vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury.
Wang H1,
Zhang K2,
Zhao L3,
Tang J3,
Gao L3,
Wei Z3.
Abstract
OBJECTIVE:
The restoration of blood flow to the brain after ischemic stroke prevents further, extensive damage but can result in reperfusion injury. The inflammation response is one of many factors involved in cerebral ischemia-reperfusion injury. This study investigated the use of vinpocetine, a drug used to treat cognitive impairment, to explore its effects on inflammation in a rat model of cerebral ischemia-reperfusion.
METHODS:
Wistar rats were randomly assigned to a control group, (n=40) a cerebral ischemia-reperfusion group (n=52) and a vinpocetine cerebral ischemia-reperfusion group (n=52). A model of middle cerebral artery occlusion was induced for 2h followed by reperfusion and the infarct size was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 6h, 24h, 3 days, and 7 days after reperfusion. The dry-wet weight method was used to measure brain water content and evaluate the extent of brain edema. Immunohistochemistry and in-situ hybridization were used to detect the expression of NF-κB and TNF-α.
RESULTS:
The NF-κB levels in ischemic brain tissue increased 6h after reperfusion and the TNF-α levels increased at 24h, both reached their peaks at day 3 then decreased gradually, but remained above the controls at day Vinpocetine decreased the levels of NF-κB and TNF-α 24h and 3 days after reperfusion.
CONCLUSION:
NF-κB and TNF-α is associated with changes in brain edema and infarct volume. Vinpocetine decreases the expression of NF-κB and TNF-α and inhibits the inflammatory response after cerebral ischemia-reperfusion.
Vinpocetine Plus by Prairie Naturals
• Mother Nature’s “Smart Pill” • Antioxidant-rich brain nutrients • Protects central nervous system • Improves blood flow • Boosts brain power • Improves memory • Reverses aging
Vinpocetine Plus
Mother Nature’s Smart Pill! Vinpocetine Plus is a synergistic formulation of powerful anti-aging and brain-boosting plant extracts – vinpocetine and blueberry. These antioxidant-rich phytonutrients are among the world’s most thoroughly researched medicinal plants for improving memory, boosting brain power, improving blood flow, reducing inflammation, reversing aging and protecting the central nervous system. Especially beneficial for students and other people concerned with memory.
